TY - JOUR AU - Стефанишин, Володимир Михайлович AU - Мальцев, Дмитро Валерійович PY - 2022/09/07 Y2 - 2024/03/28 TI - EFFECTIVENESS OF COMBINED IMMUNOTHERAPY WITH PROPES AND INFLAMAFERTIN IN SELECTIVE DEFICIENCY OF NK AND NKT CELLS IN ADULT PATIENTS WITH GENETIC DEFICIENCY OF THE FOLATE CYCLE JF - Immunology and Allergology: Science and Practice JA - Immun. and Allerg.: Sci. and Pract. VL - 0 IS - 1-2 SE - Articles DO - 10.37321/immunology.2022.1-2-02 UR - https://immunology.org.ua/index.php/journal/article/view/65 SP - 13-21 AB - Backgrounds. The results of preliminary clinicalstudies indicate the potential benefit of combined immunotherapywith Propes and Inflamafertin to compensatefor NK and/or NKT cell deficiency caused bygenetic folate cycle deficiency (GDFC) in children withautism spectrum disorders.The aim of the study: to study the effectivenessof combined immunotherapy with Propes and Inflamafertinfor NK- and/or NKT-cell deficiency in adultswith GDFC.Materials and methods. In this single-center,retrospective, controlled, nonrandomized clinicaltrial, data from the medical records of 212 adult patientsaged 19 to 50 years with GDFC (study group,SH) were analyzed. SH patients received Propes at adose of 2 ml i/m every other day at night for 3 consecutivemonths (45 injections) and Inflamafertin at adose of 2 ml i/m every other day at night for 3 consecutivemonths, alternating with Propes (45 injectionsactions). The control group (CG) consisted of34 patients of similar age and gender distribution withHDFC, who did not receive immunotherapy.Results and their discussion. The number of NKcells reached the lower limit of normal in 95 of 131 patients(72% of cases) with an initial deficiency of theselymphocytes, and the average number of NK cellsin the blood in the SH increased almost twice duringthe 3-month course of immunotherapy (p<0.05;Z<Z0.05), but returned almost to the initial level duringthe next 2 months after withdrawal of immunotherapeuticagents (р>0.05; Z>Z0.05). The number of NKTcells normalized in 136 of 174 patients (78% of cases)with an initial deficiency of these cells, and the averagenumber of NKT cells in the blood in the SH increasedby half during the course of immunotherapy(p<0.05; Z<Z0.05) and continued to increase during thenext 2 months after withdrawal of immunotropic drugs(р<0.05; Z<Z0.05). There was a correlation betweenimmunotherapy and normalization of the number ofNK- (χ2=22.786; OR=11.215; 95%CI=3.534-35.590)and NKT-cells (χ2=34.238; OR=9.54; 95%CI=4.094-22.247) in blood with an average connection betweenthese processes (criterion φ=0.387 and 0.407, respectively;C=0.361 and 0.377, respectively).Conclusions. Combined immunotherapy withPropes and Inflamafertin is an effective strategy forthe treatment of immunodeficiency caused by GDFCin adult patients. ER -