@article{Стефанишин_Мальцев_2022, title={EFFECTIVENESS OF COMBINED IMMUNOTHERAPY WITH PROPES AND INFLAMAFERTIN IN SELECTIVE DEFICIENCY OF NK AND NKT CELLS IN ADULT PATIENTS WITH GENETIC DEFICIENCY OF THE FOLATE CYCLE}, url={https://immunology.org.ua/index.php/journal/article/view/65}, DOI={10.37321/immunology.2022.1-2-02}, abstractNote={<p>Backgrounds. The results of preliminary clinical<br>studies indicate the potential benefit of combined immunotherapy<br>with Propes and Inflamafertin to compensate<br>for NK and/or NKT cell deficiency caused by<br>genetic folate cycle deficiency (GDFC) in children with<br>autism spectrum disorders.<br>The aim of the study: to study the effectiveness<br>of combined immunotherapy with Propes and Inflamafertin<br>for NK- and/or NKT-cell deficiency in adults<br>with GDFC.<br>Materials and methods. In this single-center,<br>retrospective, controlled, nonrandomized clinical<br>trial, data from the medical records of 212 adult patients<br>aged 19 to 50 years with GDFC (study group,<br>SH) were analyzed. SH patients received Propes at a<br>dose of 2 ml i/m every other day at night for 3 consecutive<br>months (45 injections) and Inflamafertin at a<br>dose of 2 ml i/m every other day at night for 3 consecutive<br>months, alternating with Propes (45 injections<br>actions). The control group (CG) consisted of<br>34 patients of similar age and gender distribution with<br>HDFC, who did not receive immunotherapy.<br>Results and their discussion. The number of NK<br>cells reached the lower limit of normal in 95 of 131 patients<br>(72% of cases) with an initial deficiency of these<br>lymphocytes, and the average number of NK cells<br>in the blood in the SH increased almost twice during<br>the 3-month course of immunotherapy (p&lt;0.05;<br>Z&lt;Z0.05), but returned almost to the initial level during<br>the next 2 months after withdrawal of immunotherapeutic<br>agents (р&gt;0.05; Z&gt;Z0.05). The number of NKT<br>cells normalized in 136 of 174 patients (78% of cases)<br>with an initial deficiency of these cells, and the average<br>number of NKT cells in the blood in the SH increased<br>by half during the course of immunotherapy<br>(p&lt;0.05; Z&lt;Z0.05) and continued to increase during the<br>next 2 months after withdrawal of immunotropic drugs<br>(р&lt;0.05; Z&lt;Z0.05). There was a correlation between<br>immunotherapy and normalization of the number of<br>NK- (χ2=22.786; OR=11.215; 95%CI=3.534-35.590)<br>and NKT-cells (χ2=34.238; OR=9.54; 95%CI=4.094-<br>22.247) in blood with an average connection between<br>these processes (criterion φ=0.387 and 0.407, respectively;<br>C=0.361 and 0.377, respectively).<br>Conclusions. Combined immunotherapy with<br>Propes and Inflamafertin is an effective strategy for<br>the treatment of immunodeficiency caused by GDFC<br>in adult patients.</p&gt;}, number={1-2}, journal={Immunology and Allergology: Science and Practice}, author={Стефанишин, Володимир Михайлович and Мальцев, Дмитро Валерійович}, year={2022}, month={Sep.}, pages={13-21} }