FEATURES OF AUTOIMMUNE AND INFLAMMATORY REACTIONS IN PERSONS WHO HAVE TREATED OR HAVE BEEN VACCINATED AGAINST COVID-19

  • Людмила Миколаївна Бєльська Senior researcher of the Department of Neuroimmunology, Ph.D. State University «Institute of Neurosurgery named after Acad. A.P. Romodanov of the National Academy of Sciences of Ukraine»
  • Микола Іванович Лісяний Chief department of intracerebral tumors of the Institute of Neurosurgery named after acad. A.P. Romodanov, NAMS of Ukraine, Kyiv, membercor. NAMSU, professor.
  • Антоніна Іванівна Ключникова Senior researcher of the Department of Neuroimmunology, Ph.D. State University “Institute of Neurosurgery named after Acad. A.P. Romodanov of the National Academy of Sciences of Ukraine”
  • Олена Петрівна Красиленко Employee of State University “Institute of Neurosurgery named after Acad. A.P. Romodanov of the National Academy of Sciences of Ukraine”, Doctor of Medicine, neurologist.
Keywords: Covid infection, inflammation, longterm effects of antibodies to neuroantigens.

Abstract

The aim of the study was to examine the level of autoantibodies to certain neuroantigens and the state of inflammatory reactions in individuals with mild to moderate COVID-19 infection who were vaccinated and those who were not.

Materials and methods. Serum was tested in 34 individuals who were routinely tested for antiviral antibodies after disease or vaccination to determine whether they were immune to COVID-19 and possible revaccination.

Results. Serum levels of medium molecules and C-reactive protein were highest in those who had COVID-19 infection compared to those vaccinated or those who were not. Serum levels of medium moleculesn and C-reactive protein were incredibly elevated in those who were vaccinated compared to those who were not ill and were not vaccinated, indicating the
development of a minor inflammatory response and good antigenicity of vaccines. Levels of autoantibodies to serum was increased in both groups of sick and vaccinated persons in comparison with persons who were not ill.

Conclusion. The results indicate the activation of humoral neuroautoimmune reactions, which may contribute to the development of both remitting and progressive neurological complications in the long period after infection.

Published
2022-09-09
How to Cite
Бєльська, Л., Лісяний, М., Ключникова, А., & Красиленко, О. (2022). FEATURES OF AUTOIMMUNE AND INFLAMMATORY REACTIONS IN PERSONS WHO HAVE TREATED OR HAVE BEEN VACCINATED AGAINST COVID-19. Immunology and Allergy: Science and Practice, (1-2), 22-28. https://doi.org/10.37321/immunology.2022.1-2-03

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