CONTENT OF CELLS OF INNATE AND ACQUIRED IMMUNITY IN PERIPHERAL BLOOD IN BRAIN TUMORS
Glial tumors, which have varying degrees of malignancy, make up more than half of all neoplasms of the brain, but the mechanisms of oncotransformation have not yet been fully understood, and immune reactions play an important role in these processes. The purpose of the study was to determine the relationship between the absolute number of lymphocytes and neutrophils in peripheral blood in glial tumors of various degrees of anaplasia of surgical treatment.
Materials and methods. 71 clinical cases of patients with glial brain tumors, 25 meningitis and 20 metastatic tumors at different stages of treatment, namely before surgery and on the 5-7th day after surgery, were studied. Among the 71 patients with glial tumors of various degrees of anaplasia who were initially operated on, there were 40 patients with glioblastomas (IV degree of anaplasia), 15 patients with anaplastic astrocytomas (III degree of anaplasia), 16 patients with diffuse astrocytomas (I-II degree of anaplasia). The comparison (control) group consisted of 28 patients with non-oncological diseases of the central nervous system. The age of patients with brain tumors and the comparison group was 35-65 years. Peripheral blood parameters were determined on a Mindray 3000 plus automatic hematology analyzer. For the analysis of immunological indicators in the blood, the absolute content of neutrophils and lymphocytes and such indices as the ratio of the absolute content of neutrophils to the absolute content of lymphocytes (n/l) were determined. The statistical processing of the obtained results was carried out using the Statistica 8 program with the determination of the arithmetic mean and square deviation (m ± σ) and the t-Student indicator.
Research results. The concentration of lymphocytes, neutrophils and platelets in the peripheral blood of patients depends on the degree of anaplasia of glial brain tumors. In malignant glial tumors, glioblastomas and anaplastic astrocytomas, the relative indicators of n\l increase significantly compared to benign tumors. In the postoperative period for 5-7 days, there is no restoration of the content of the studied sub populations of immune cells in the peripheral blood, which indicates the role of not only tumor, but also other factors that cause changes in immunity in malignant gliomas.
Conclusions. Determination of the ratio of the absolute content of immune cells among themselves in peripheral blood can serve as an informative indicator of disorders in innate and acquired links of immunity.