• A. Kurchenko MD, Professor, Head of the Department of Clinical Immunology and Allergology with a section of Medical Genetics, O.O. Bogomolets National Medical University
  • G. Fedoruk MD, candidate of Medical Sciences, Associate Professor of the Department of Clinical Immunology and Allergology with a section of Medical Genetics, O.O. Bogomolets National Medical University
  • V. Savchenko Ph.D., senior researcher lab. of Immunology, SI «Institute of Urology named after Academician O.F. Vozianov NAMS of Ukraine»
Keywords: vaccination against COVID-19, antibodies, B cells, NK cells, CD314, CD94, immunoadaptive effect.


The aim of the study – to study the effect of Esberitox on humoral (by the level of total antibodies and quantitative detection of IgG to the Spike antigen of the SARS-CoV-2) and cellular (by determining the phenotypes of lymphocyte populations CD3, CD4, CD8, CD56, CD19, CD45 with an assessment expression of activating CD314 (NKG2D) and inhibitory CD94 (NKG2A) receptors on NK cells and lymphocytes) links of the immune system before vaccination and after receiving the first dose of the vaccine.

Materials and methods. The study involved 30 clinically healthy volunteers (with informed consent for examination and administration of the drug), who had not been ill with Covid-19 during the previous 3 months before entering the study project, who took Esberitox, and selected according to the relevant criteria for the control group – 20 clinically healthy people. The studies were carried out three times: three days before vaccination – before starting Esberitox, immediately before vaccination, and before the second vaccination – 21 days after receiving the first dose of the vaccine.

Results. The use of the drug Esberitox according to the selected scheme stimulates the production of specific antibodies to Covid-19 – in the case of normalization of the number of B cells. The drug is an immunomodulator that affects the regulatory activating CD314 (NKG2D) and inhibitory CD94 (NKG2A) receptors.

Conclusions. The study showed that the drug Esberitox, prescribed as an immunomodulator, during the vaccination process stimulates the production of specific antibodies to COVID-19, if the number of B cells is normalized. The drug Esberitox is capable of influencing the regulatory activating and inhibitory receptors of NK and T cells, which play an important role in nonspecific cellular defense against the SARS-CoV-2 coronavirus and can be used in the schemes of immunorehabilitation of postcovid syndrome in immunocompromised patients.


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