EVALUATION OF CLINICAL EFFICIENCY OF ALLERGEN IMUNOTHERAPY IN PATIENTS WITH ALLERGIC DISEASES

  • Світлана Зубченко Associate Professor, Department of Clinical Immunology and Allergology, Danylo Halytsky Lviv National Medical University
  • Ігор Гайдучок сandidate of Medical Sciences, Associate Professor, General director of LLC «Lviv Medical Institute»
  • Сергій Юр’єв Assistant of the Department of Clinical Immunology and Allergology with the course of medical genetics of the National Medical University named after O. Bogomolets
  • Валентина Чопяк MD of Sciences, Professor, Department of Clinical Immunology and Allergology, Danylo Halytsky Lviv National Medical University
Keywords: allergen immunotherapy, SKIT, SLIT, VAS, component-resolved diagnostics

Abstract

Pathogenetically determined method of treatment of allergic diseases is specific allergen immunotherapy (AIT). There are different ways to administer the allergy vaccine: from traditional – subcutaneous (SKIT), to relatively new –sublingual (SLIT). The effectiveness of allergen immunotherapy and safety for each patient has been linked to many studies.
Purpose. Analysis of the clinical effectiveness of AIT using different methods of allergy vaccine (SLIT and SKIT) in patients with allergic diseases.
Materials and methods. The observation group consisted of 165 patients with various allergic diseases, including 73 (44.2%) female and 92 (55.8%) male, aged
32.6 ± 2.4 years. Performed general clinical, laboratory, instrumental, specific allergology, including component research. For AIT used ALXOID (a mixture of polymerized allergen extracts), for SLIT – sublingual spray ORALTEK, manufactured by Inmunotek, Spain. Evaluation of clinical efficacy at different stages of the three-year treatment period was performed on a visual analog scale (VAS).
Results. The assessment was performed in three groups: 87 (52.7%) individuals (SLIT group), 78 (47.3%) individuals (SKIT group) and 42 patients with allergic diseases (control group). It was determined that in patients with AIT, regardless of the method of administration of allergy vaccine, there was a significant decrease in the assessment of VAS upper nasal, upper non-nasal and lower symptoms after 36 months of therapy compared with the control group. In contrast, no significant difference in symptom assessment between the SLIT and SKIT groups was found at all stages of follow-up (p> 0.05).
Conclusions. A three-year course of AIT vaccine manufactured by Inmunotek, Spain, regardless of the route of administration (sublingual or subcutaneous), demonstrated the accuracy of personalized allergy vaccine selection based on molecular studies and high clinical efficacy in patients with different types of allergic diseases, as confirmed by VAS.

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Published
2020-12-24
How to Cite
Зубченко, С., Гайдучок, І., Юр’єв, С., & Чопяк, В. (2020). EVALUATION OF CLINICAL EFFICIENCY OF ALLERGEN IMUNOTHERAPY IN PATIENTS WITH ALLERGIC DISEASES. Immunology and Allergology: Science and Practice, (3-4), 71-78. https://doi.org/10.37321/immunology.2020.3-4-08