INFLUENCE OF THE CONTENT OF ULTRAFINE PARTICLES IN ATMOSPHERIC AIR ON THE COURSE OF NEONATAL SEPSIS

  • О. В. Власова Candidate of Medical Sciences, assistаnt of the Department of Pediatrics and Children’s Infectious Diseases of HSEE of Ukraine “Bukovinian State Medical University”
  • Л.О. Безруков Doctor of Medical Sciences, professor of the Department of Pediatrics and Children’s Infectious Diseases of HSEE of Ukraine “Bukovinian State Medical University”
  • О.О. Шахова Candidate of Medical Sciences, assistаnt of the Department of Pediatrics and Children’s Infectious Diseases of HSEE of Ukraine “Bukovinian State Medical University”
  • Л.І. Власик Doctor of Medical Sciences, professor, Head of the Department of Hygiene and Ecology of HSEE of Ukraine “Bukovinian State Medical University”
Keywords: sepsis, newborns, ultrafine particles, pollution, xenobiotics

Abstract

Introduction. The effect of low-intensity xenobiotics due to bioaccumulation in the mother’s tissues and their release into the bloodstream during pregnancy can have a pathogenic effect on the fetus, especially in sensitive periods of its development. Therefore, the aim of the study was to evaluate the effect of the content of ultrafine particles (UFPs) in the air during fetal development of newborns with sepsis and to analyze its key indicators.
Materials and methods. For analysis, selected indicators of ultrafine particles with a size of 10-20 nm, which when inhaled by pregnant women are able to penetrate into its bloodstream and, accordingly, into the circulatory system of the fetus. Two clinical observation groups were formed. The first group was formed by 17 patients with neonatal sepsis, in which in one of these periods the integrated index of UFPs in the air exceeded 1.0. The second group included 35 newborns with sepsis, in which in one of these periods the UFPs content in the atmospheric period was less than 1.0.
Results. In children of group I, there is a certain imbalance of markers of the systemic inflammatory response of the body to infection in the form of a significant decrease in anti-inflammatory IL-10, as well as increased serum presepsin. Thus, in group I the content of presepsin was 907.1±198.2 pg/ml, and in the comparison group 672.6±152.4 pg/ ml (p> 0.05). The content in the serum of immunoglobulins A, G, M in the subgroups of comparison
did not differ significantly.
Conclusion. The content in the air of ultrafine particles with a size of 10-20 nm during fetal development does not significantly affect the gestational age, the general nature of the intensity of sepsis therapy and the duration of its treatment in the hospital. A characteristic feature of patients in the main group can be considered a tendency to a higher level of serum presepsin at low levels of anti-inflammatory interleukin-10.

Downloads

Download data is not yet available.

References

Brook RD, Rajagopalan S, Pope CA 3rd, Brook JR, Bhatnagar A, Diez-Roux AV, et al. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation. 2010;121(21):2331-78. doi: 10.1161/CIR.0b013e3181dbece1

Johnson RL Jr. Relative effects of air pollution on lungs and heart. Circulation.2004;109(1):5-7 doi:10.1161/01. CIR.0000110643.19575.79

Neupane B, Jerrett M, Burnett RT, Marrie T, Arain A, Loeb M. Long-term exposure to ambient air pollution and risk of hospitalization with community-acquired pneumonia in older adults. Am J Respir Crit Care Med. 2010;181(1):47-53. doi: 10.1164/rccm.200901-0160OC

Pope CA 3rd, Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, et al. Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation. 2004;109(1):71-7. doi: 10.1161/01. CIR.0000108927.80044.7F

Kurt OK, Zhang J, Pinkerton KE. Pulmonary health effects of air pollution. Curr Opin Pulm Med. 2016;22(2):138-43. doi: 10.1097/ MCP.0000000000000248

Rice MB, Ljungman PL, Wilker EH, Dorans KS, Gold DR, Schwartz J, et al. Long-term exposure to traffic emissions and fine particulate matter and lung function decline in the Framingham heart study. Am J Respir Crit Care Med. 2015;191(6):656-64. doi: 10.1164/rccm.201410-1875OC

Sly PD, Flack F. Susceptibility of children to environmental pollutants. Ann N Y Acad Sci. 2008;1140:

Published
2020-12-24
How to Cite
Власова, О. В., Безруков, Л., Шахова, О., & Власик, Л. (2020). INFLUENCE OF THE CONTENT OF ULTRAFINE PARTICLES IN ATMOSPHERIC AIR ON THE COURSE OF NEONATAL SEPSIS. Immunology and Allergology: Science and Practice, (3-4), 29-33. https://doi.org/10.37321/immunology.2020.3-4-03