STAN IMMUNITETU AND CORRECT REMEDIES IN BORIES ON SEASONAL ALERGIC RINIT ON ONLY DESTRUCTED INTESTINAL MICROBIOCENOSIS THAT KARCHATOUS STATUS

  • Tatyana Bondarenko associate professor of the Department of Clinical, Laboratory Immunology and Allergology of the National Medical Academy of Postgraduate Education (NMAPE) named after P.L. Shupik, candidate of medical sciences. 04112, Kiуv, st. Dorogozhitskaya, 9
  • Viktor Litus Head of the Department of Clinical, Laboratory Immunology and Allergology of the National Medical Academy of Postgraduate Education (NMAPE) named after P.L. Shupik, Doctor of Medical Sciences, Professor
  • Alexey Kuznetsov assistant of the Department of Clinical, Laboratory Immunology and Allergology of the National Medical Academy of Postgraduate Education (NMAPE) named after P.L. Shupik. 04112, Kiуv, st. Dorogozhitskaya, 9
  • Larisa Kuznetsova Professor of the Department of Clinical, Laboratory Immunology and Allergology of the National Medical Academy of Postgraduate Education (NMAPE) named after P.L. Shupik, Doctor of Medical Sciences, Professor. 04112, Kiуv, st. Dorogozhitskaya, 9
  • Oleg Nazar Associate Professor of the Department of Clinical, Laboratory Immunology and Allergology of the National Medical Academy of Postgraduate Education (NMAPE) named after P.L. Shupik, Candidate of Medical Sciences, Associate Professor. 04112, Kyiv, st. Dorogozhitskaya, 9
Keywords: seasonal allergic rhinitis, intestinal microbiocenosis, nutritional status

Abstract

Introduction. Nutrition is one of the most significant environmental factors that affects the functional state of all organs and systems, determines the state of adaptive capabilities of the body, promotes health, or vice versa, causes the development of diseases, contributes to their chronicity and progress. The functional state of organs and systems by a patient with seasonal allergic rhinitis (ATS) is determined by the reserves of energy, plastic and regulatory support that cells receive with food. Inadequate nutrition is also one of the causes of secondary immunodeficiency, which has a negative effect on the course of ATS.

Materials and methods. We studied 75 patients with ATS with mild and moderate disorders of the pathological process and taking into account disturbances in intercellular cooperation, an increase in IL-4, specific IgE and TNF-α against the background of a nutritional disorder occurring with mild immunological indicators of systemic immunity.

Research results. Three groups of patients were distinguished: 1 group of 25 patients with a lack of body weight; Group 2 – 25 patients whose body weight was within normal limits; Group 3 – 25 overweight patients and Group 4 (control) comparisons (healthy people) – 25 people.

Discussion of research. The data obtained indicate the effectiveness of the developed therapy, which includes dietary correction and a comprehensive differentiated approach in the appointment of pre- and probiotics. The effectiveness of treatment is indicated by the positive dynamics of the clinical manifestations of intestinal dysbiosis.

Conclusions. In addition to positive changes in intestinal symptoms, in patients with ATS, there was a positive dynamics in the gastrointestinal tract, as well as normalization of specific and non-specific indicators of immunity. The effectiveness of the specific treatment of patients with ATS against intestinal dysbiosis is increased by 85%.

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Published
2019-12-23
How to Cite
Bondarenko, T., Litus, V., Kuznetsov, A., Kuznetsova, L., & Nazar, O. (2019). STAN IMMUNITETU AND CORRECT REMEDIES IN BORIES ON SEASONAL ALERGIC RINIT ON ONLY DESTRUCTED INTESTINAL MICROBIOCENOSIS THAT KARCHATOUS STATUS. Immunology and Allergy: Science and Practice, (4), 26-34. https://doi.org/10.37321/immunology.2019.04-04